It is a fact of life that if we do not bond with other people we often get depressed. Depressed individuals are usually not interested, and do not “feel like” being with other people, thus isolating themselves. A cascade of events follow, isolated individual, less bonding takes place, less activity less people interaction, depression increases and it perpetuates a vicious circle. You must get out of the vicious circle. Isolation is not the solution to anything, unless you have TB (tuberculosis) and need to be in isolation to prevent from spreading infection to your community.
If your isolation is causing you to be depressed, reach out, seek help from a recognized therapist, perhaps you might need medication. If you are averse to taking medication, check with your physician see if strenuous exercise will be another option for  you  to get out of your depressed state.

If you notice that you frequently are tired, sleep deprived, attacked by negative thinking, and that you have lost your motivation, and out of nowhere you came up with suicidal thoughts, have lost interest in sex; these elements are going to take you to depression avenue. Help is out there and you must seek it. A research shows that depression is the number eight leading cause of death in the United States of America. It is OK to call for help, you are not alone.